Browsing by Author "Kolo John Baba"

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    An overview of the general characteristics, pathogenicity, transmission, and diagnosis of human papilloma virus (HPV)
    (Gadau Journal of Pure and Allied Sciences, 2022-02-02) Yahaya G.; Magaji Ibrahim; Kolo John Baba; Suleiman Kafilat Olayemi
    Mucous membrane infections are brought on by the double-standard DNA virus known as human papillomavirus (HPV). Cervix cell alterations are caused by a sexually transmitted illness. E6 and E7 oncogenes play a critical role in HPV infection. Finding these genes to identify HPV strains, particularly the HPV16 strain, will have a significant impact due to its exceptional sensitivity, the dielectric electrochemical biosensor stands out among other pathogen detection methods. Recent evidence suggests that E6 and E7 are also important in inhibiting the innate immune response of the host cell to HPV. Viral replication is mediated by the E1 and E2 proteins in conjunction with other biological stimuli. E2 has also been linked to viral and cellular transcriptional regulation. Despite decades of research, the function of other viral proteins still remains unclear. Therefore, analysis of Human Papilloma Virus (HPV) characteristics, pathogenicity, transmission and diagnosis were reviewed. We concluded that we now have the tools and methodologies necessary to answer this critical question about viral tropism. The discovery of efficient treatments to cure or prevent HPV-induced illness is just as vital as studying the underlying mechanisms of HPV pathogenesis. The identification of drugs specifically to treat HPV infection has not been highly successful due to the complexities of the HPV life cycle and the limited number of enzymatic activities identified for HPV proteins. The development of drug treatments for existing HPV disease is an important undertaking that deserves further attention. In this regard, the development of therapeutic vaccines and self-protection are promising area of investigation and needs to be further supported.